The Compound Zicao Oil was prepared from the zicao moisturizing cream in the Ming Dynasty's book Youke Golden Needle.It was prepared with medicinal herbs such as Radix Lithospermi，Borneolum Syntheticum，Caulis Lonicerae，and Radix Angelicae Dahuricae.It has the effects of clearing heat，detoxifying，cooling blood and relieving pain.Professor Zhang Baoqing has flexibly applied Compound Zicao Oil to treat pediatric eczema，mild anal fissure，infant red buttocks，cheilitis，herpes simplex and other pediatric skin diseases according to its drug broadening clinical treatment scope，and achieved good clinical results，which can provide some reference and guidance for the clinic.