To observe the effect of self-designed bushenhuoxue decoction and acupuncture combined with hyperbaric oxygen on postoperative rehabilitation of patients with spinal fracture and spinal cord injury.Methods:A total of 78 cases of spinal fracture combined with spinal cord injury admitted to Qinghai Red Cross Hospital from January 2017 to June 2018 were selected，and they were divided into a control group and an observation group according to the random number table，with 39 cases in each group.The 2 groups of patients were treated with surgical decompression and fracture reduction internal fixation，and the postoperative treatment and nursing were adopted in our hospital.On this basis，the control group was treated with hyperbaric oxygen，and the observation group was treated with modified Bushen Huoxue Decoction and acupuncture.The changes in pain perception，sphincter function，sensory，motor function and nerve function Franke classification were evaluated before and after 6 months of treatment，and the levels of brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)in serum were determined.The levels of tumor necrosis factor-α(TNF-α)，c-reactive protein(CRP)and procalcitonin(PCT)were monitored before and 1 week after surgery.Results:Compared with before treatment，the pain，muscle function，sensory function，motor function and neural function Franke classification rate of 2 groups after 6 months' treatment were significantly improved.The pain VAS score and sphincter function scores were significantly decreased，while the ASIA，sensory and motor score were significantly elevated.Comparison between groups，the index changes in the observation group was more obvious，and the difference was statistically significant(P<0.05); After 6 months of treatment，the levels of BDNF and NGF in the 2 groups were significantly increased(P<0.05); The observation group was significantly higher than the control group，with statistically significant differences(P<0.05).Compared with the preoperative results，the serum levels of inflammatory cytokines TNF-α，CRP and PCT were significantly increased in the 2 groups 1 week after surgery(P<0.05).Compared between groups，the observation group was significantly lower than the control group(P<0.05).Conclusion:The modified Bushen Huoxue Decoction，acupuncture combined with hyperbaric oxygen is good to promote the rehabilitation of patients with spinal fracture and spinal cord injury，which has a good effect，is conducive to reducing pain，improving the function of sphincter，sensory，motor and neurological functions of patients after surgery，and reducing the levels of postoperative inflammatory factors，has certain clinical application value.