To analyze the clinical effects of electroacupuncture on gouty knee arthritis of damp-heat accumulation syndrome and its influence on inflammatory body of NOD-like receptor protein 3(NLPR3).Methods:From January 2016 to January 2018，86 patients with gouty knee arthritis of damp-heat accumulation syndrome who met the inclusion criteria in Yan'an Hospital of TCM were selected as the subjects.According to the order of visiting，they were divided into a control group and an observation group，with 43 cases in each group.Both groups were given routine western medicine to treat inflammation and relieve pain，daily life diet guidance，exercise guidance.On the basis of routine treatment，the observation group was given acupuncture at bilateral Zusanli(ST36)，Sanyinjiao(SP6)，Fenglong(ST40)and the affected side Ashi points，and low-frequency pulse therapy apparatus was used to stimulate the Liangqiu(ST34)，Dubi(ST35)，Xuehai(SP10)and Neixiyan(EX-LE4)around the knee.Both groups of patients were treated for 2 weeks for a course of treatment.The knee pain score(VAS)，swelling score，functional activity，serum NLRP3，PYCARD，CASPl gene mRNA expression，serum inflammatory markers(IL-1B，IL-2，IL-4，IL-6，IL-10，TNF-α)were compared between the 2 groups before and after treatment.After completion of treatment，the clinical efficacy of the 2 groups was evaluated.The adverse drug reactions/side effects of the 2 groups were collected and compared.Results:1)After 2 weeks of treatment，VAS，swelling score and knee joint activity of the 2 groups were significantly decreased，and the study group was significantly lower than the control group(P<0.05).2)After treatment，the levels of serum inflammatory factors IL-1B，IL-2，IL-4，IL-6，IL-10 and TNF-α in the 2 groups were significantly decreased than before treatment，and the observation group was significantly lower than those in the control group(P<0.05). 3)After treatment，the expression of NLRP3 gene mRNA in serum of the 2 groups was significantly increased than that before treatment，and the observation group was higher than the control group.The expression of PYCARD and CASPl gene mRNA in the observation group was significantly decreased than that before treatment，and the observation group was lower than the control group(P<0.05).4)After treatment，the clinical total effective rate of the observation group was significantly higher than the control group(P<0.05).5)There was no significant difference in the rate of adverse drug reactions/side effects between the 2 groups(P>0.05).Conclusion:Electroacupuncture assisted anti-inflammatory and analgesic drugs can effectively improve the expression of NLPR3 gene mRNA in patients with gouty knee arthritis of damp-heat accumulation syndrome，reduce the level of serum inflammation，promote the improvement of clinical symptoms and improve the clinical efficacy，which is safe and reliable，and has high clinical value.