Based on the theory of the “liver being innate basis of women”，the author emphasized that the liver depression is the basis of the hyperplasia of the mammary gland，which is closely related with the theory of the physiological and pathological mechanism of the hyperplasia of the mammary gland.The disease is located in liver，spleen，stomach and kidney，which is related to the dysfunction of liver，spleen，and kidney and the function of the viscera such as Chong Ren.It treatment focuses on maintaining liver function and regulating the liver and regulating the emptying of the liver.The treatment takes the liver as the pivot，although the syndrome is changeable，does not leave its essence.Therefore，the methods of soothing the liver and regulating qi at the same time，such as activating blood circulation and removing blood stasis，invigorating the spleen and resolving phlegm，warming up the liver and kidney，regulating the absorption and Chong Ren，etc，and application of the prescription modified Zhitong Xiaojie Decotion treatment.The effect is remarkable.