Chronic skin ulcer is a common and frequently-occurring disease.The treatment period is long and the clinical treatment effect is not ideal.It is a research hotspot to seek effective therapeutic drugs and methods.Mesenchymal stem cells(MSCs)participate in multiple aspects of wound repair through the functions of low immunogenicity，multiple differentiation potentials，and wide sources，etc.，through the functions of paracrine/autocrine effect and differentiation to epithelial cells，in order to promote refractory wounds.The healing provides a new means of clinical application and research.The authors reviewed the role of MSCs in the healing of chronic skin ulcer wounds and the regulatory functions of Traditional Chinese Medicine，providing evidence for clinical and basic research.