Interpretation based on the guidelines on prevention and treatment of novel coronavirus pneumonia by Chinese Medicine(CM) in Hubei province. Coronavirus disease 2019(COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 is an acute infectious disease.The main symptoms of most patients in the early stage were hiding fever, dry cough, weakness, poor appetite and thick-greasy tongue coating. The disease belongs to the epidemic category, which is due to damp-heat epidemic poison in Chinese medicine. The main lesion is in the lung and spleen, and the basic pathogenesis is “dampness, poison, stasis and closure”. This disease is the epidemic disease, which needs to be distinguished from the “warm disease in the four season ”. The foothold should be aimed at the pathological manifestations and characteristics of damp-heat epidemic poison, because damp-heat epidemic poison is the main cause of this disease. Therefore, in the early stage, although there was cold dampness block, the cold dampness transforming to heat was the normal state. During the course of the disease, heat, asthma, stasis, detoxification and weakness are caused. From the pathogenesis of the disease, there are wet poison, heat poison, stasis poison. So the treatment should be around damp-heat epidemic poison and chasing evil is the first important point. Dividing away the damp heat and pestilence, and releasing the Qi are the main measures.Controlling the early and advanced treatment is the key to reduce critical illness and mortality.The guidelines have been strengthened since the first edition in terms of extensive CM prevention and health care, standardized integrated CM and western medicine treatment, and full use of CM to promote the rehabilitation of patients.