A large proportion of patients with severe acute respiratory syndrome coronavirus 2 infection showed abnormal liver function during the antiviral treatment,which led to sepsis or septic shock,thus causing widespread concern among clinicians. Over the years,traditional Chinese medicines (TCMs) have played an important role in the clinical application of liver injury protection,and its efficacy has been widely recognized. The paper reviewed the mechanism of liver injury caused by 2019-nCoV,the pathological changes of liver injury caused by viruses and drugs,and the TCMs and preparations commonly used to prevent and cure liver injury,in order to provide reference support for the prevention and treatment of liver injury in patients with Novel Coronavirus Pneumonia (NCP).