According to the literature reports on Coronavirus Disease 2019(Covid-19),combining with the relevant ancient books of traditional Chinese Medicine,the pathogenic characteristics of 2019-nCoV were discussed from the standpoint of traditional Chinese medicine. It was found that the pathogenic parts of the disease were variable and varied,and showed the characteristics of wetness,cold and dryness. It can enter from the mouth, nose and couli, so “Weifen” and “Taiyang” were affected by pathogenic factors almost at the same time,which damaged the defense qi, so that the disease could enter the viscera directly, causing the disease of blood and tissue fluid together. And then, the difference between the pathogenic of pestilence and the pathogenic of mixed disease, as well as the mechanism of pestilence inducing persistent diseases were discussed. Traditional Chinese Medicine(TCM) has its own unique theoretical system to recognize and treat diseases. In the treatment of Covid-19,traditional Chinese physician should grasp the following principles: Intergratlng Chinese and Western Mediclne; combining the disease and syndrome. Keep in mind the general principles of TCM treatment of diseases: Observe its pulse and syndrome, know what is wrong with it, and treat it according to the syndrome; Guard against transmission and transformation,and first secure the good place free from Pathogen; The manifestation of an epidemic is cold or hot,and do not only use cold and cool herbs in the treatment. The recommended prescription is “heng san zi” Prescription,which was used to treat cold epidemic or the cold epidemic in Huangzhou (now Huanggang City, Hubei Province) in Song Dynasty.Besides, the recommended special medicine is based on Shennong's Classic of Materia Medica modern pharmacological research and the pathogenic characteristics of disease pathogen,and three kinds of traditional Chinese medicine: Muxiang, Xuchangqing and Cimicifuga are selected.