To explore efficacy and safety of Mailuo Shutong Pills in patients with varicocele.Methods:A total of 120 patients with varicocele admitted in Qingdao Municipal Hospital from November 2018 to April 2019 were selected as study objects, and randomly divided into control group and observation group, with 60 cases in each group.Both groups were treated with high-selectivity ligation of spermatic vein by laparoscope.The control group was given Aspirin Enteric-coated Tablets, on the basis of this, patients in the observation group were given Mailuo Shutong Pills.After the operation, the quality of semen, recurrence and complications were compared between the 2 groups.Results:The cure rate in the observation group was 93.33%, and that in the control group was 76.67%.The difference between the 2 groups was statistically significant(P<0.05).The total effective rate in the observation group was 96.67%, and that in the control group was 90.00%.There was no statistical difference between the 2 groups(P>0.05).After 6 months of the treatment, semen volume and sperm density in the observation group were higher than those in the control group, and liquefaction time and deformity rate were lower than those in the control group.The differences between the 2 groups were statistically significant(P<0.05).The total incidence of complications in the observation group was 6.7%, which was significantly lower than 26.7% in the control group.The difference between the 2 groups was statistically significant(P<0.05).Conclusion:Mailuo Shutong Pills can significantly improve the quality of postoperative semen in patients with varicocele, reduce the recurrence rate and the incidence of complications, and provide ideas for clinical treatment.