Most scholars in literatures of traditional Chinese medicine(TCM)think that the pathogenesis of phlegm, blood stasis and toxin makes the treatment of arteriosclerosis occlusion(ASO)rather difficult.This paper summarizes the theoretical basis of etiology and pathogenesis of phlegm, blood stasis and toxin in ASO, and explores the mechanism of detoxifying and phlegm-resolving as well as blood stasis-removing and vessel-dredging methods in the treatment of ASO with blood stasis in vessels and internal amassment of heat-toxin, referring to typical clinical cases.To further study the role of Jiedu Huatan Quyu Decoction in the intervention of ASO lipid metabolism, hemorrheology, a variety of inflammatory factors and other factors, so as to lay a foundation for deepening the theory of phlegm, blood stasis and toxin in TCM.To shorten treatment time of curing ASO, enhance efficacy and reduce amputation rate, and thus to look for a better way to treat the disease by integrated traditional Chinese and western medicine.