To explore efficacy of acupuncture and medicine combined with syndrome differentiation and Treatment on functional dyspepsia(FD).Methods:A total of 80 FD patients in Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine from March 2017 to January 2019 were selected as study objects and divided into control group(39 cases)and observation group(41 cases)according to the order of admission.The control group was treated with Deanxit combined with domperidone for 4 weeks.The observation group was treated with auxiliary acupuncture and decoctions of Chinese materia medica after syndrome differentiation for 4 weeks.Changes of symptom score, SF-36 quality of life score, electrogastrogram indexes, gastrointestinal hormone, symptom score, gastric motility and efficacy when entering the groups and at the end of the treatment were observed and compared between the 2 groups.Results:At the end of the treatment, the effect of acupuncture and medicine combined with syndrome differentiation and treatment on the symptom score, gastric emptying time, gastrin(GAS), somatostatin(SS)was better than that in the control group, while the effect of improving the quality of life score, amplitude of gastric electrical activity, frequency of gastric electrical activity, motilin(MTL)and total effective rate was better than that in the control group(P<0.05).Conclusion:The combination of acupuncture, medicine and syndrome differentiation can improve gastrointestinal function, gastric motility, symptoms and quality of life in FD patients.