To explore the effects of Neiguan(PC6)acupoint pressing combined with ginger application on motilin level in patients with hyperemesis gravidarum.Methods:A total of 70 patients with hyperemesis gravidarum who were treated in Zhangjiagang Hospital of Traditional Chinese Medicine from January 2017 to March 2019 were selected and divided into a control group(35 cases)and an observation group(35 cases).The control group was given routine symptomatic rehydration support treatment.On this basis, the observation group was treated with Neiguan(PC6)acupoint pressing combined with ginger application.The treatment time of both groups was 7 days.The clinical efficacy and TCM symptom scores of vomiting clear water, nausea and vomiting after ingestion, dizziness and anorexia, nausea and vomiting were observed.The vomiting frequency, time to stop vomiting, hospitalization days, PUQE and NVPQOL were recorded.Serum motilin was measured by radioimmunoassay before and after treatment.The test strip method was used to detect the levels of uroketones in the 2 groups, and the differences in the above indicators were compared between the 2 groups at the same time.Results:The clinical efficacy of the observation group(94.29%)was significantly higher than that of the control group(74.29%)(χ2=5.285, P=0.022); after treatment, the scores of vomiting clear water, vomiting while eating, dizziness, anorexia, nausea and vomiting in the 2 groups were significantly decreased, and the observation group was lower than those in the control group(P<0.01); the levels of urea ketone body in both groups were significantly decreased, and the observation group was lower than those in the control group(P<0.01); motilin in both groups were significantly increased and the observation group was lower than those in the control group(P<0.01).The PUQE and NVPQOL scores in the 2 groups were significantly decreased and the observation group was lower than those in the control group(P<0.01); the vomiting frequency, antiemetic time and hospitalization time in the observation group were significantly better than those in the control group(P<0.05); in addition, the recurrence rate in the observation group was 5.71%(2/35)and that in the control group was 22.86%(8/35), with statistical differences between the 2 groups(χ2=4.200, P=0.040).Conclusion:Neiguan(PC6)acupoint pressing combined with ginger application is effective in the treatment of hyperemesis gravidarum.It can effectively improve the level of urinary ketone body and motilin, shorten the time of vomiting and hospitalization, reduce the number of vomiting, and improve the quality of life.