During the outbreak of novel coronavious pneumonica(NCP),we headed to the front line of Wuhan epidemic area to carry out TCM therapies which demonstrated certain effect.Along with the advancement of clinical practice,we found that although the major pathology of the disease lies in the lung,the liver-spleen differentiation and treatment are vital for improving prognosis as well.Liver Qi stagnation and mental disorder is the common pathogenesis of NCP and patients are often observed with emotional abnormalities.The root cause is liver Qi stagnation and mental disorder is the manifestation,the disorder of the lung affects the liver,metal restricts wood,which significantly aggravate the disease.Thus,the prescription should give consideration to soothing liver and tranqulization,improving sleep,relieving uneasiness of mind and reducing mental stress.Dysfunction of spleen is an important pathogenesis of NCP,hence the principle of reinforcing spleen and regulating stomach should be adopted as one of ground rules.In summary,liver Qi stagnation and spleen deficiency are the key mechanism throughout the disease progression.It could be a reasonable approach to focus on the regulation of liver and spleen to improve efficacy.