Today,with high incidence of drug-induced diseases,transdermal drug delivery has become an important way in clinical medication.In order to reduce inhibition effect of natural skin barrier function on drug absorption,various kinds of methods to promote skin's transdermal absorption emerge in endlessly.In an emergency or severe case,this method can significantly increase drug permeability,to improve clinical efficacy.But for chronic diseases,especially for patients who need long-term medication,frequent daily use will increase skin permeability to a certain extent,destroy natural structure of the skin,affect its normal physiological functions and lead to occurrence of some skin diseases.So,from the skin structure,skin function as well as relationship between skin disorders and diseases,under the premise of insight into the drug transdermal absorption principle,this paper puts forward that there should be certain selectivity in promoting drug transdermal absorption,aiming to guide patients with correct application of drug transdermal technology,and reduce the occurrence of drug-induced diseases.