血府逐瘀汤加减治疗慢性盆腔炎疗效及部分疗效机制研究
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青海省卫生厅医药卫生科研指导性计划课题(Y2016-34)


Study on Efficacy of Modified Xuefu Zhuyu Decoction in Chronic Pelvic Inflammation and Part of Its Mechanisms
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    摘要:

    目的:观察血符逐瘀汤加减对慢性盆腔炎炎症应激反应、免疫功能影响。方法:选取2015年8月至2017年8月青海省康乐医院收治的慢性盆腔炎患者200例作为研究对象,按照随机数字表法分为对照组和观察组,每组100例。对照组予常规西医治疗,观察组在对照组基础上加用血府逐瘀汤治疗,连续治疗2周。观察2组治疗前、治疗2周后炎症应激反应、血液流变学、临床症状体征积分、免疫功能及药物不良反应。比较组间临床疗效率。结果:治疗后观察组患者下腹坠胀痛/腰骶酸痛、月经紊乱、附件区压痛/扪及包块、子宫活动度差/粘连固定积分、TNF-α、CRP、CD8+、全血高切黏度、全血低切黏度、血细胞比容、红细胞沉降率下降幅度较对照组更大,而IL-2、IL-10、临床总有效率、CD3+、CD4+、CD4+/CD8+较对照组提升更高,差异有统计学意义(P<0.05)。结论:血符逐瘀汤可改善慢性盆腔炎全身炎症应激反应,提升血流动力学,提高免疫功能和疗效,是治疗该疾病的良好方法。

    Abstract:

    To observe effects of modified Xuefu Zhuyu Decoction on inflammatory stress response and immune function in chronic pelvic inflammation.Methods:A total of 200 patients with chronic pelvic inflammation admitted in Qinghai Kangle Hospital from August 2015 to August 2017 were selected as study objects and divided into control group(100 cases)and observation group(100 cases).The control group was treated with conventional western medicine for 2 weeks, and the observation group was treated with Xuefu Zhuyu Decoction on the treatment basis of the control group for 2 weeks.The inflammatory stress response, hemorheology, clinical symptom and sign score, immune function and adverse drug reactions were observed before the treatment and after 2 weeks of the treatment.Clinical effective rates were compared between the groups.Results:Compared with the control group, the decent degrees of scores of lower abdominal distending pain/lumbosacral aching pain, menstrual disorder, tenderness/masses in the adnexa area, and poor uterine activity/adhesion and fixation score, TNF-α, CRP, CD8+, high shear viscosity of whole blood, low shear viscosity of whole blood, hematocrit and erythrocyte sedimentation rate in patients of the observation group were larger.While IL-2, IL-10, the total clinical effective rate, CD3+, CD4+ and CD4+/CD8+ were increased more significantly than those in the control group(P<0.05).Conclusion:Xuefu Zhuyu Decoction can improve the systemic inflammatory stress response, hemodynamics, immune function and efficacy in chronic pelvic inflammation, which is a good method to treat the disease.

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金秀萍,马英兰.血府逐瘀汤加减治疗慢性盆腔炎疗效及部分疗效机制研究[J].世界中医药,2020,(03).

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  • 收稿日期:2019-07-02
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  • 在线发布日期: 2020-03-16
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