To evaluate effects of Tibetan medicine bloodletting therapy on local and systemic inflammatory factors in acute gout.Methods:A total of 30 cases of acute gout admitted in Changdu Hospital of Tibetan Medicine from November 2017 to August 2018 were selected as study objects and treated with Tibetan medicine bloodletting therapy.In the local, 5 mL blood was taken when bloodletting 0 mL, 30 mL, 60 mL and 90 mL.And 5 mL blood was taken from the median cubital vein when bloodletting 0 mL, 30 mL, 60 mL and 90 mL.WBC, CRP, blood UA, IL-1β, TNF-α and HIF-1α levels were tested.Results:There was statistical difference between the systemic 90 mL and 0 mL UA after the bloodletting(P<0.01), while there was no significant difference between the 90 mL and 0 mL WBC and CRP(P>0.05).There was statistically significant difference between the systematic 90 mL and 0 mL HIF-1α levels after the bloodletting(P<0.01), while there was no significant difference between the 90 mL and 0 mL IL-1β and TNF-α levels(P>0.05).There was statistical difference between the local 90 mL and 0 mL IL-1β, TNF-α and HIF-1α levels after the bloodletting(P<0.01).HIF-1α was weakly correlated with both IL-1β and TNF-α.Conclusion:Bloodletting therapy can improve local tissue hypoxia and reduce local UA level, which leads to a decrease of IL-1β, TNF-α and HIF-1α, and finally relieves symptoms of acute gout.