To explore the active compounds of Qingxuan Zhike Granule for treatment of pediatric Coronavirus disease 2019 (COVID-19).Methods:With the help of the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP),the chemical constituents and action targets of mulberry leaf,peppermint,bitter apricot seed,platycodon root,debark peony root,orange fruit,dried tangerine peel,tatarian aster root,liquorice root in Qingxuan Zhike granules were retrieved.The genes corresponding to the target were queried through databases such as UniProt and GeneCards,and then Cytoscape 3.7.2 was used to build a compound-target (gene) network,gene ontology (GO) function enrichment analysis was perform through DAVID,based on the Kyoto Encyclopedia of Genes and Genomes (KEGG ) Path enrichment analysis,its mechanism was predicted.Results:The compound-target network contains 141 compounds and 292 corresponding targets.The key targets are PTGS2,ESR1,HSP90AA1,CALM1,AR,etc.GO function enrichment analysis obtained 339 GO entries (P<0.05),of which 244 were biological process (BP) entries,33 were cell composition (CC) entries,and 62 were molecular function (MF) entries.The KEGG Path enrichment analysis obtained 96 signal pathways (P<0.05),involving small cell lung cancer,non-small cell lung cancer,and T cell receptor signaling pathways.The molecular docking results showed that the core compounds such as quercetin,Kaempferol,luteolin and the like had similar affinity to the COVID-19 virus as the recommended drugs.Conclusion:The active ingredients in Qingxuan Zhike granules may regulate multiple signaling pathways by acting on targets such as PTGS2,HSP90AA1,and ESR1,thereby inhibiting COVID-19.