Qingfei Paidu decoction is composed of Maxing Shigan decoction, Shegan Mahuang Decoction (Chinese date and Chinese magnoliavine fruit were taken out), Xiaochaihu Decoction (ginseng and Chinese date were taken out), Wuling powder, Juzhijiang decoction, common yam rhizome and cablin patchouli herb. The above five classical prescriptions are all from Shanghan Zabing Lun by ZHANG Zhongjing, the medical saint. Among them, Maxing Shigan decoction can relieve superficies and ventilate lung Qi, clear heat and relieve panting; Shegan Mahuang decoction (Chinese date and Chinese magnoliavine fruit were taken out) can ventilate lung Qi and dispell phlegm, descend Qi and relieve cough; Xiaochaihu Decoction (ginseng and Chinese date were taken out) can harmonize the pathogen in the half-superficies and half-interior. Juzhijiang decoction can activate Qi and dispel phlegm; Wuling powder can diffuse dampness; cablin patchouli herb can resolve toxins and remove dampness, common yam rhizome can invigorate the spleen and supplement the lung. The combination of cassia twig and liquorice root can support Yang and the healthy energy. The combination of those medicines can clear lung-heat and remove toxicity and is suitable for light, normal, and heavy Coronavirus Disease 2019 patients. Some scholars have shown through network pharmacological analysis that Qingfei Paidu decoction plays an overall regulatory role on the body through multiple components and multiple targets.