The raw material of Houttuynia cordata Injection is a single ingredient，H. cordata. The quality of H.cordata directly affects the quality of H.cordata injection.H.cordata is widely distributed in the wild with abundant resources.However, the wild resources of H.cordata have gradually declined with the increasing demand.At present, the supply of H.cordata is mainly from the agricultural planting.In 2006, the adverse events of H.cordata Injection aroused the public's extensive attention with far-reaching influence on the traditional Chinese medicine injection.This paper summarizes the identification, resource distribution, breeding, cultivation, chemical composition analysis, determination of pesticide residue, and heavy metal elements of H.cordata, aiming to standardize the production of raw materials.It provides safe and effective medicinal materials for clinical medicine of traditional Chinese medicine and production of pharmaceuticals for enterprises, and provides theoretical basis for perfecting quality standards of Houttuynia cordata Injection and evaluation after market.Meanwhile, it plays a guiding role in researches on the raw materials of other traditional Chinese medicine injections.