To explore the clinical effects of Shuxuening Injection combined with clopidogrel hydrogen in the treatment of acute cerebral infarction and the influence of nerve function defection,inflammatory factors and the oxidative stress. Methods:A total of 148 cases of cerebral infarction were selected as research objects in the Sixth Hospital of Wuhan,Affiliated to Jianghan University from February 2017 to June 2018 according to random number table method and were divided into a control group and an observational group,with 74 cases of each group. The control group was given clopidogrel hydrogen sulfate combined with routine therapy,while the observational group was given Shuxuening Injection based on the treatment of the control group. The treatment lasted for 2 weeks. The clinical effects,the indexes of blood rheology,the relative indexes of nerve function (MBP,NSE,H-FABP,GFAP),oxidative stress index (SOD,MDA and ROS),inflammatory factors (sVCM-1,TNF-α,IL-18) and the level of HMGB1 were observed of 2 groups. Results:After treatment,the red blood cells deposit,whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,MBP,NSE,H-FABP,GFAP,NIHSS score decreased significantly of 2 groups. The above indicators changed more obviously of the observational group,the differences were statistically significant (P<0.05). Compared with those before treatment,the level of sVCM-1,TNF-α,IL-18 and HMGB1 decreased significantly of 2 groups. The above indexes of the observational group was obviously lower than that of the control group after treatment (P<0.05). After treatment,the level of MDA and ROS decreased significantly of 2 groups,and the level of SOD increased significantly of 2 groups. The above indicators changed more obviously of the observational group,the differences were statistically significant (P<0.05). The total effective rate of the observational group after treatment (91.89%) was significantly higher than that of the control group (78.38%),and the difference was statistically significant (P<0.05). Conclusion:Shuxuening Injection combined with clopidogrel hydrogen in the treatment of cerebral infarction can improve the blood rheology,reduce inflammatory reaction,reduce the symptoms of nerve function defection,reduce the level of oxygen free radicals,thus improve the clinical therapeutic effects.