In this study,we observed the effects of seasonal changes on the levels of hormones related to the sympathetic-adrenal medullary system in normal subjects and patients with bronchial asthma,and further revealed the biological mechanism of “ kidney corresponding with winter”. Methods:In the spring equinox,summer solstice,autumn equinox and winter solstice of 2018,the blood samples of normal people and bronchial asthma patients were collected. Enzyme-linked immunosorbent assay (ELISA) was used to detect the contents of plasma epinephrine (E) and norepinephrine in normal and bronchial asthma patients (NE),changes in the content of adrenal medulla hormone (ADM). Results:The contents of E,NE and ADM in plasma of normal people increased in spring and autumn,and the lowest in winter. The contents of E,NE and ADM in plasma of bronchial patients increased in winter,but decreased in spring and autumn. Conclusion:The sympathetic-adrenal medulla system-related hormone levels have a significant seasonal correlation; the onset of bronchial asthma is associated with a seasonal rhythm disorder in the sympathetic-adrenal medullary system hormone levels. The theory of “kidney corresponding with winter” has a biological basis at the level of “sympathetic-adrenal medulla system”.