To establish a qualitative and quantitative quality standard control method for the Menshi Chaihu Lizhong Granules.Methods:The Bupleurum chinense and Radix Astragali were qualitatively identified by thin-layer chromatography by the Menshi Chaihu Lizhong Granules.The content of baicalin in Menshi Chaihu Lizhong was determined by high performance liquid chromatography.Diamonsil-C18 column(200 mm×4.6 mm,5.0 μm)was used.The mobile phase was gradient eluted with methanol-0.1% aqueous acetic acid,the flow rate is 1.0 mL/min,the detection wavelength is 280 nm,the column temperature is 25 ℃,and the injection volume is 10 μL.Results:The chromatographic spots of Bupleurum chinense and Radix Scutellariae were clearly separated and there was no interference in the negative; the regression equation was y=2 907 186.561 0x+21 224.436 6(r=0.999 8),and baicalin had a good linear relationship in the range of 0.12 μg-1.20 μg.The average recovery was 99.45% and the RSD was 2.48%.Conclusion:The established method is reliable and scientific,and can be used for thin-layer identification andqualitative and quantitative quality control of the Menshi Chaihu Lizhong Granules.