To analyze prescription regularity of TCM prescription and medication for the treatment of thyroid nodules，based on the traditional Chinese medicine (TCM) inheritance support platform system.Methods:This study chose academic literatures related to TCM treatment of thyroid nodules in CNKI database，VIP database，Wanfang database over the past 10 years as the data source，screened and established database to analyze the core drugs and their channel tropism，property and flavor，compatibility law，and core composition，by means of frequency statistics，association rules，and complicated system entropy clustering and other data mining methods.Results:A total of 103 formulas selected and 145 kinds of Chinese medicines were involved.And the analysis showed that there were 18 drugs with usage frequency of 20 and more than 20，32 common drug pairs.And 14 core drug combination，and 7 new prescriptions were explored.Conclusion This research，which is based on TCM inheritance support software，to analyze prescription regularity of TCM for the treatment of thyroid nodules，is helpful to provide new ideas for clinical treatment and provide a reference for prescription drugs.