The mechanism of intervention of Sichuan lovage rhizome on heart failure was discussed by using network pharmacology, which laid a foundation for further study on the role of Sichuan lovage rhizome in heart failure.Methods:According to Therapeutic Target Database (TTD), Online Mendelian Inheritance in Man (OMIM)and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), the targets of heart failure were retrieved, Comprehensive database of traditional Chinese medicine (Symmap) were used to search for the targets of heart failure and thoracic and hypochondriac stabbing symptoms, then, Uniprot database was used to exclude the non-human targets.Next,the human targets of heart failure and thoracic and hypochondriac stabbing symptoms were obtained, mapping the human target corresponding to the chemical composition of Sichuan lovage rhizome OB value ≥30 inquired by Symmap,to further screening the active ingredients.PPI network analysis was constructed by String database and Cytoscape 3.2.1 software.Pathway analysis was carried out by The Database for Annotation, Visualization and Integrated Discovery (DAVID), and network diagram of TCM-target-component was constructed by Cytoscape 3.2.1 software.Results:Twelve targets of Sichuan lovage rhizome for heart failure, one target for thoracic and hypochondriac stabbing symptoms, 47 corresponding ingredients of Sichuan lovage rhizome for heart failure were obtained.12 targets were analyzed by KEGG pathway using DAVID database, and 29 related pathways of Sichuan lovage rhizome for heart failure were obtained.Conclusion:Sichuan lovage rhizome can improve cardiac function and treat heart failure by inhibiting inflammation, regulating apoptosis and improving vasoconstriction function.