To explore and analyze the effect of Jiawei Xiangsha Liujunzi Decoction on the expression of paxillin (post protein) and RelA (apoptotic related protein) in gastric cancer rats by inhibiting Wnt signaling pathway.Methods:120 healthy adult Wistar rats were randomly divided into control group and observation group, 60 rats in each group.Gastric cancer modeling treatment were done for 2 groups of rats.Rats in control group were randomly divided into untreated group, 8 weeks after treatment (saline) group and 12 weeks after treatment (saline) group, 20 rats in each group.The rats in the observation group were randomly divided into untreated group, 8 weeks after treatment (decoction) group and 12 weeks after treatment (decoction) group, 20 rats in each group.Paxillin and RelA were observed before treatment, 8 weeks after treatment and 12 weeks after treatment of the two groups.Results:There was significant difference in the quality of rats between the two groups before and after treatment (P<0.05).There was no significant difference in the quality of rats between the two groups before treatment (P>0.05).After treatment, the quality of rats in the two groups decreased, but the degree of reduction in the observation group was significantly lower than that in the control group (P<0.05).The levels of wnt-1, paxillin and RelA in the two groups before and after treatment were significantly different (P<0.05).There was no significant difference in the levels of wnt-1, paxillin and RelA between the two groups before treatment (P>0.05).After treatment, the levels of wnt-1, paxillin and RelA in the two groups decreased, but the levels of wnt-1, paxillin and RelA in the observation group were significantly lower than those in the control group (P<0.05).Conclusion:Jiawei Xiangsha Liujunzi Decoction can effectively inhibit the expression of paxillin and RelA in gastric cancer rats by inhibiting wnt.