To optimize extraction process of Dayuan Granules.Methods:Based on Box-Behnken design-response surface method,the sum of the extraction yield,magnolol,and magnolol content were the evaluation index and the extraction process conditions of Dayuanyin Granules was optimized.Results:The optimal value of Dayuanyin Granules was 2.42 extraction times,0.96 h extraction time,10 times the amount of solvent added,and the predicted value OD=0.948.According to the actual production,the optimal conditions were selected as 55 minutes extraction time and 10 times the amount of water added.Extracted twice,OD=0.895.Conclusion:The optimized extraction process has been verified to have high repeatability and stable results.