To explore the long-term effects of Xiaoer Xiaoji Oral Liquid combined with Western medicine on children with bronchial asthma.Methods:A total of 66 children with bronchial asthma treated in Hefei Third People's Hospital from January 2018 to June 2019 were randomly divided into a contro group(n＝33)and an observation group(n＝33)according to random number table.In the control group,budesonide aerosol inhalation and montelukast sodium granules were given orally.The observation group was treated with Xiaoer Xiaoji Oral Liquid on the basis of the control group.The groups were treated for 3 months.Clinical efficacy,and immune related indicators were compared; In the follow-up for 6 months outside the hospital,the above indicators were compared.Results:The total effective rate in the observation group was significantly better than that in the control group(P<0.05).After 3 months of group treatment,the percentage of EOS,levels of IgA,IgE and IgG in the observation group were significantly improved and better than those in the control group and before treatment(P<0.05); EOS percentage,IgA,IgE,and IgG levels in the observation group were significantly better than those in the control group(P<0.05),and the recurrence rate was slightly lower than that in the control group(P>0.05).Conclusion:Xiaoer Xiaoji Oral Liquid combined with montelukast sodium and budesonide can reduce the inflammation level,improve the immune function of children with bronchial asthma in a long-term,improve the clinical efficacy,and reduce the recurrence rate to a certain extent.