To observe the clinical efficacy of Ganmai Dazao Decoction in treating cancer-related depression.Methods:A total of 72 patients with cancer-related depression admitted to Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were randomly divided into a control group and an observation group,with 36 cases in each group.Both groups were treated with Xiaoaiping Tablets,a kind of Chinese patent medicine.And the observation group was added with Ganmai Dazao Decoction.The course of the treatment for the 2 grous were 28 days．The Self-rating depression scale(SDS)score,the levels of 5-HT,Hcy,TNF-α,IL-6,the levels of natural killer(NK)cells and T cells(CD3+,CD4+,CD8+,CD4+/CD8+)levels and the changes of QLQ-C30(V3.0)were compared.Results:The SDS score of the observation group was obviously lower than that of the control group and the difference was statistically significant(P<0.05).After treatment,there were statistically significant differences on the improvement levels of 5-HT,TNF-α,IL-6 between the 2 groups,and the improvement in the observation group was obviously better than that in the control group(P<0.05).After treatment,there were statistically significant differences on the immunity index levels of CD3+,CD4+and CD4+/CD8+ between the 2 groups.The score difference in physical function,role function,emotional function,social function,total health status,fatigue,and insomnia score of life quality was statistically significant between 2 groups after treatment(P<0.05).Conclusion:Ganmai Dazao Decoction combined with Xiaoaiping Tablets can be used in the treatment of cancer-related depression,which can significantly alleviate the depression,and improve immune function and quality of life．