To investigate the relationship between the distribution of traditional Chinese medicine (TCM) syndromes in patients with hepatitis B cirrhosis and liver reserve function and effective liver blood flow, and to explore the characteristics of TCM syndromes in patients with hepatitis B cirrhosis from the perspective of liver function metabolism.Methods:A total of 163 patients with hepatitis B cirrhosis admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were selected as the research objects.Based on the information of the four diagnostics and the “syndrome testing with prescriptions”, the TCM syndrome types were summarized, and the indocyanine green 15-min retention rate (ICG-R15), effective liver blood flow (EHBF), Alb, and MELD scores among different TCM syndrome types were analyzed. Differences between groups such as Child-pugh score, etc., were analyzed. Results:The TCM syndromes of hepatitis B and cirrhosis were mainly liver and kidney yin deficiency, accounting for 48.46%. There are significant differences in ICG-R15, EHBF, Alb, PA, PT, and Child-pugh classifications among different TCM syndrome types. ICG-R15 and Child-pugh scores showed the trend of liver depression and spleen deficiency syndrome/liver and gallbladder damp-heat syndrome>liver and kidney yin deficiency syndrome>blood stagnation syndrome>spleen and kidney yang deficiency syndrome; EHBF showed the trend of liver and gallbladder damp-heat syndrome>liver stagnation and spleen deficiency syndrome> blood stasis obstructing collaterals> liver and kidney yin deficiency> spleen and kidney yang deficiency. EHBF in the syndrome of liver and kidney yin deficiency showed a downward trend with the decrease of Child-pugh grade（P=0.008）. Conclusion:The liver reserve function and hepatic effective blood flow of patients with hepatitis B cirrhosis are consistent with the evolutionary stages of TCM syndromes. The effective blood flow of liver and kidney yin deficiency has a tendency to decrease with the decrease of liver reserve function.