To investigate the effects of Xianqi Fuzheng Granule combined with Sanjiao acupuncture on immunity and CEA and CA724 in patients with Ⅲ-Ⅳ colorectal cancer.Methods:A total of 66 cases of patients with stage Ⅲ-Ⅳ colorectal cancer treated in Yantai Traditional Chinese Medicine Hospital from Sep.2018 to Sep.2019 were collected and were randomly divided into a treatment group(n=33)，and a control group(n=33).The treatment group was treated with chemotherapy+Xianqi Fuzheng Granules+Sanjiao acupuncture，and the control group was treated with chemotherapy+Xianqi Fuzheng Granules+Sanjiao acupuncture，with 14 d/cycle and 4 cycles.The cancer-related fatigue and quality of life，TCM symptom scores，T lymphocyte subset，serum tumor marker levels，efficacy，adverse reactions between the 2 groups were compared.Results:After treatment，the QLQ-C30 scores of all dimensions，CD3+，CD4+，CD4+/CD8+ and serum CEA，CA724，and CA19-9 levels in the 2 groups increased and those in the treatment group were significantly higher than those in the control group(P<0.05).After treatment，the TCM symptom score and the percentage of CD8 in the 2 groups were significantly lower than before the treatment，those in the treatment group were significantly lower than in the control group(P<0.05).The DRC of the treatment group(90.91%)was higher than that of control group(63.64%，P<0.05).The incidence of nausea，vomiting and neurotoxicity were lower in the treatment group than in the control group(33.33% vs 57.58%，36.36% vs 63.64%，P<0.05).Conclusion:Based on chemotherapy，the combination of Xianqi Fuzheng Granules and the Sanjiao acupuncture method can reduce the levels of CEA and CA724 in patients with Ⅲ-Ⅳ colorectal cancer，improve their immune function，reduce adverse reactions，cancer-related fatigue，improve quality of life，with accurate efficacy.