To explore the effects of Qingre Huashi prescription combined with quadruple chemotherap on the patients with chronic atrophic gastritis with erosion and its influences on the PGR and G-17.Methods:A total of 90 patients with chronic atrophic gastritis with erosion patients admitted to Chinese Medicine Hospital Affiliated to Xinjiang Medical University from December 2016 to May 2018 were selected as the research object and were divided into an experimental group and a control group according to computer-generated number table method,with 45 cases in each group.The patients in the control group were treatment with quadruple chemotherap combined with routine Western medicine,and the experimental group was treatment with Qingre Huashi Prescription combined with quadruple chemotherap.The efficacy and the levels of PGR and G-17 were compared between the 2 groups.Results:After treatment,the histopathology effective rate of the experimental group was 91.11%,and there was no significant difference between the control group of 82.22%(P>0.05); while the TCM symptom effective rate of the experimental group was 97.78%,which was higher than that of the control group of 66.67%,with statistically significant(P<0.05).The TCM symptom score of the experimental group was(6.89±3.45)points,which was lower than that of the control group(10.51±4.03)points,with statistically significant(P<0.05).In the the experimental group,the chronic inflammation score and atrophy score were all lower than those of the control group,with statistically significant(P<0.05).The PGR of the experimental group was(6.88±2.41),there was no significant difference between the control group(7.24±2.36)(P>0.05),while the level of G-17 of the experimental group was(7.31±1.32)pmol/L,which was higher than that of the control group(5.43±1.30)pmol/L,with statistically significant(P<0.05).Conclusion:Qingre Huashi prescription combined with quadruple chemotherap on the patients with chronic atrophic gastritis with erosion can help to improve the efficacy on patients,and promote the symptom improvement of the patients.