To clarify the characteristic effect of acupuncture Zulinqi(GB41)on the low-frequency oscillation amplitude of brain function in migraine without aura by using functional magnetic resonance.Methods:From January 2015 to February 2016,a total of 19 patients with migraine without aura who were admitted to the Department of Neurology,Dongzhimen Hospital of Beijing University of Chinese Medicine and the Department of Acupuncture and Moxibustion of Dongzhimen Hospital of Beijing University of Chinese Medicine were selected as the research objects.State functional magnetic resonance imaging matched 18 healthy subjects undergoing a needle-free functional magnetic resonance scan as a control.The differences in the amplitude of low-frequency oscillations in brain function areas between migraine patients and normal subjects and the changes in the amplitude of low-frequency oscillations before and after acupuncture were compared and analyzed.Results:Compared with the healthy control group,the brain regions with significantly increased low-frequency oscillation amplitude in migraine patients without aura were the hippocampus,parahippocampal gyrus,and right superior temporal gyrus,while the significantly weakened brain regions were the left cuneiform lobe and supratopia back to the other brain areas; compared with before acupuncture,the brain areas where the amplitude of low-frequency oscillations are significantly increased after acupuncture are the right central anterior and posterior gyrus,and the brain areas that are significantly weakened are the right precuneus,middle frontal gyrus,etc.and in other brain area.Compared with the healthy control group,the brain areas in which the amplitude of low-frequency oscillations were significantly increased after acupuncture Zulinqi(GB41)in migraine patients without aura were the right central anterior gyrus,central posterior gyrus and other brain areas,and the significantly weakened brain areas were such as the left cuneiform and precuneus.Conclusion:Acupuncture Zulinqi(GB41)has a characteristic regulating effect on the functional abnormalities of multiple brain areas in migraine without aura,which may provide functional imaging support for the therapeutic effect of acupuncture intervention.