To investigate the effects of Maka Renshend Decoction on immune function of mice.Methods:Antibody production was measured by carbon clearance test,mouse peritoneal macrophage phagocytic chicken red blood cell test,sheep red blood cell-induced delayed-type allergy test in mice,ConA-induced mouse lymphocyte transformation test (MTT method),and Jerne modified slide method Cell number test,determination of mouse serum hemolysin,and the effect of Maka Renshen Decoction on the immune function.Results:Compared with the blank control group, the low, middle and high dose Maka Renshen Decoction groups could significantly increase the phagocytic index of mice (P<0.05 or P<0.01). The low, medium and high dose groups of Maka Renshen Decoction can significantly increase the phagocytosis rate of mouse macrophages and chicken red blood cells (P<0.05 or P<0.01) and phagocytic index (P<0.01). The medium and high-dose groups of Maka Renshen Decoction can significantly increase the swelling of the toes of mice (P<0.05), and the high-dose group of Maka Renshen Decoction can obviously increase the number of hemolytic plaques in mice (P<0.01).Conclusion:Maka Renshen Decoction can improve the function of monocyte-macrophage,cellular immunity and humoral immunity in mice.