To investigate the effects of Shenqi Jiedu Decoction with GP regimen on serum macrophage inhibitory factor 1(mic-1)，matrix metalloproteinase-9(mmp9)and immune function in patients with advanced non-small cell lung cancer(NSCLS).Methods:A total of 84 patients with advanced NSCLC admitted to Bao'an Authentic Traditional Chinese Medicine Therapy Hospital from March 2019 to December 2019 were selected as research objects and were divided into a control group and an observation group by random digital table method，with 42 cases in each group.The control group received GP regimen chemotherapy.On this basis，the observation group was treated with Shenqi Jiedu Decoction.The clinical efficacy and adverse reactions/ side effects during treatment were compared between 2 groups.Traditional Chinese medicine(TCM)syndrome score，the level of serum MIC-1 and MMP-9，immune function index(CD3+，CD4+，CD8+，CD4+/ CD8+)were also compared between the 2 groups before and after treatment.Results:The effective rate(47.62%)and disease control rate(83.33%)in the observation group were significantly higher than those in the control group(26.19%，64.29%)(P<0.05).The TCM syndrome score(11.38±2.76)in the post-treatment observation group was significantly lower than that in the control group(14.71±2.48)(P<0.05).After treatment，the level of serum MIC-1(584.28±82.16)pg/mL and MMP-9(170.63±115.27)ng/Lin the observation group were significantly lower than those in the control group［(832.13±90.84)pg/mL，（228.59±121.38)ng/L］(P<0.05).After treatment，CD3+(64.72±6.83）%，CD4+(35.76±4.23）%and CD4+/CD8+(1.62±0.41）%in the observation group were significantly higher than those in the control group［(50.35±3.46）%，（29.28±3.41）%，1.02±0.11)%］while CD8+(22.17±3.26)％was significantly lower than the control group(28.23±2.16)％(P<0.05).The incidence of leukopenia，thrombocytopenia，anemia and gastrointestinal reactions in the observation group(16.67%，4.76%，9.52%，19.05%)was significantly lower than that in the control group(35.71%，19.05%，26.19%，40.48%)(P<0.05).Conclusion:Shenqi Jiedu Decoction combined with GP regimen can reduce the expression of mmp-9 and mic-1 in advanced NSCLC patients.Compared with the single use of GP regimen，it can improve the curative effect，reduce the score of TCM syndrome，improve the immune function of patients，and reduce the incidence of adverse reactions.Plus the higher effect than that of chemotherapy alone，this therapy is worthy of clinical application.