To evaluate the effects of Guanxin Danshen Dripping Pills in the treatment of patients with coronary heart disease.Methods:Cochrane Library，PubMed，EMBASE，Chinese Journal Full-text Database，Chinese Biomedical Journal Literature Database，etc.were searched to screen the clinical research of Guanxin Danshen Dropping Pills in the treatment of coronary heart disease.The time was up to June 2019.The quality of the included literature was evaluated according to the Cochrane Handbook，and the RevMan 5.3 software was used for Meta analysis.Results:A total of 22 studies involving 2137 patients were included.Meta analysis results showed that Guanxin Danshen Dripping Pills combined with conventional Western medicine treatment can further reduce the incidence of cardiovascular events in patients with coronary heart disease(P=0.01); and can improve the symptoms of angina in patients with coronary heart disease(P<0.000 1).Meanwhile，Guanxin Danshen Dripping Pills combined with conventional Western medicine treatment can further reduce the levels of high-sensitivity C-reactive protein(hs-CRP)and interleukin-18(IL-18)in patients with coronary heart disease(P<0.000 01，P=0.002); it can improve the related indexes of hemorheology(P<0.05).A total of 2 papers reported adverse events，including 3 cases in the Guanxin Danshen Dripping Pill treatment group and 6 cases in the control group.There was no significant difference between the 2 groups(P>0.05).Conclusion:Guanxin Danshen Droping Pills combined with conventional therapy in the treatment of cardiovascular events，is better to the single Western group in reducing the incidence of cardiovascular incident，relieving angina，reducing inflammatory response and improving the state of hemorheology etc.，without increasing the incidence of adverse reactions，suggesting Guanxin Danshen Droping Pills combined with routine Western medicine may be the effective method in the treatment of coronary heart disease.