To compare the clinical effect of Jianpi Shengxue Tablets and ferrous sulfate tablets on preventing iron deficiency anemia in infants.Methods:A total of 200 pregnant women with a history of anemia who were treated in the Third Xiangya Hospital of Central South University from January 2018 to July 2018 were selected as the research objects and were randomly divided into a control group and an observation group with 100 cases in each group.The observation group patients were given Jianpi Shengxue Tablets，3 tablets/time，2 times/day; Patients in the control group were given ferrous sulfate tablets，1 piece/time，2 times/d.Both groups of patients took the medicine continuously for 9 months.The difference of the mother and baby's anemia rate，mother's serum ferritin，transferrin level，postpartum TCM syndrome scores and adverse reactions between the 2 groups of patients at 9 months postpartum were observed.Results:All the indexes in the observation group were significantly better than those in the control group.Among them，none of the breast-fed children had anemia,which was significantly better than that in the control group.Meanwhile,the incidence of gastrointestinal adverse reactions was fewer in the observation group.Conclusion:Maternal supplementation of Jianpi Shengxue Tablets is more effective in preventing iron deficiency anemia in infants than ferrous sulfate，and is safer，and has the value of further clinical promotion.