Biomarkers are markers or/and functional molecules derived from organs,tissues,cells,and subcellular organelles,which can mark changes in the structure or function of organs,tissues,cells,and subcellular organs.Drug-induced liver injury(DILI)generally involves clinical phenotypes of almost all acute and chronic liver diseases,and dynamic monitoring of its occurrence and development has always been a huge challenge in the field of basic and applied pharmacology.In addition to the traditional ALT,ASP,AST and other indicators,many new biomolecules have been reported as biomarkers.The development of omics technology also provides more biomarker molecules for DILI detection.This paper reviews the drug types that cause liver damage and biomarkers of liver injury,to provide selection and guidance for DILI research.