Thyroid nodules refer to scattered lesions caused by abnormal growth of thyroid cells in the region.5%～15% of thyroid nodules are malignant.Combined with modern medical treatment，Professor TONG Xiaolin inherites the traditional syndrome differentiation and treatment model，and opens the idea of “classification，stage，and syndrome differentiation” to systematically explain the types，development，and transformation of thyroid nodules and thyroid cancer.Classification and staging based on thyroid nodules and thyroid cancer(according to the natural evolution process can be divided into 3 stages：depression，stasis，and deficiency)，clinical practice of prevention and treatment of thyroid nodules and thyroid cancer under the guidance of the system of syndrome differentiation are constructed.