To analyze the research progress of existing gout related models in vivo and in vitro，and to put forward the prospect and assumption for shaping the gout disease model more in line with the clinical characteristics.Methods:According to the related literature sorted out in recent thirty years，the existing gout related in vivo and in vitro models were analyzed from the aspects of modeling method，model carrier selection，modeling principle and model characteristics，and the breakthrough point of gout model establishment was considered.Results:Gout related models were mainly hyperuricemia model，gouty arthritis model and uric acid nephropathy model.The rodents and poultry animals were commonly used in model animals，and the modeling methods were mainly induced by diet or exogenous drugs to simulate their manifestations such as high blood uric acid，urate deposition and inflammation reactions.Uric acid metabolism and inflammation related cells were common in model cells，which can directly reflect the pathological changes.Conclusion:The existing gout related models are difficult to fit the whole clinical progressive characteristics，and models for inducing urate deposition are relatively lacking.Quail has a similar metabolic pathway of uric acid to humans and is an ideal animal for establishing gout disease model.