To explore the association and potential mechanism of Tripterygium wilfordii and Sjogren's syndrome based on network pharmacology.Methods:By searching the TCMSP database，combined with oral bioavailability and drug-like analysis，the main active ingredients and action targets in Tripterygium wilfordii were screened; the GEO database was searched to screen for predicted targets for Sjogren's syndrome，and effective compounds were mapped to disease targets; Cytoscape software was used to construct the target interaction network of Tripterygium compound-Sjogren's syndrome; PPI protein interaction network was constructed through Bisogenet package; Bioconductor platform and R software were used to perform GO function enrichment analysis and KEGG pathway enrichment analysis.Results:A total of 22 active ingredients of Tripterygium wilfordii were screened and 413 targets were identified.466 differential genes for Sjogren's syndrome were identified from the GEO database; the effective compound-Sjogren's syndrome network includes a total of 28 nodes and 41 interactions.The key active compounds are kaempferol，ligandrin，β-sitosterol，triptolide，and zhebein; 11 core proteins were obtained through the PPI network; GO enrichment analysis mainly involved a total of 295 biological processes (BP)，3 cell compositions (CC)，and 46 molecular functions (MF); relevant entries mainly involve arachidonic acid metabolism，eicosanoid acid，fatty acids，prostaglandins and other organisms，oxidative stress，and the activities of various enzymes，etc; KEGG pathway was enriched and screened to obtain 19 signaling pathways，including arachidonic acid metabolism，serotonergic synapses，TNF signaling pathway，a variety of apoptosis，VEGF signaling pathway，IL-17 signaling pathway，NF-κB signaling Pathways，etc.Conclusion:This study used the network pharmacology method to preliminarily analyze the multi-component，multi-target，and multi-path characteristics of Tripterygium wilfordii in treating Sjogren's syndrome，providing a reference for the implementation of subsequent clinical and scientific research-related work.