To explore the potential mechanism of intervention effect of Yinchen Wuling Powder on primary biliary cholangitis(PBC) based on network pharmacology and molecular docking.Methods:The chemical composition and target of Yinchen Wuling Powder were retrieved by traditional Chinese medicine systems pharmacology(TCMSP).Disease targets were collected by GeneCard and OMIM databases.Cytoscape3.7.2 software was used to construct the compound-target network of medicinal materials.Gene ontology(GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were carried out by R language.The core active compound in the pharmacological network is molecularly docked with the farnesoid X receptor(FXR)，and the binding activity of recommended chemical drugs and FXR were compared.Results:The compound-target network screened out the core active compounds of Yinchen Wulingsan as quercetin，isorhamnetin，β-sitosterol，atropirin A，Artemisia serrata，Daphne flavonoids，flavonoids，3β-Beta Phthalooxy atractylone，dihydroquercetin，demethoxy chromogenone，etc.2189 GO entries were obtained(P<0.05)，and KEGG pathway enrichment analysis yielded 155 signal pathways(P<0.05).The molecular docking results showed that the affinity of the core active compound and FXR was similar to the recommended drug.Conclusion:The potential mechanism of Yinchen Wuling Powder's intervention on PBC may be quercetin，isorhamnetin，β-sitosterol，atropyrin A，Artemisia halodendron，Daphne flavonoid，Yinchen flavone，3β-ethylphthalide active compounds such as oxyatractone，dihydroquercetin，and demethoxyl chromogenone can act on AKT1，JUN，MAPK1，RELA，IL6，MAPK14，EGFR，ESR1，FOS，CCND1 and other targets by binding to FXR point adjusts multiple signal pathways to play a role.