In order to obtain the optimal preparation process of Xanthii Fructus oil liposomes.Methods:Lecithin and cholesterol was used as membrane materials，liposomes were prepared by a thin film dispersion hydration method.The weight difference between free drugs and drug-containing liposomes was used to separate them by ultracentrifugation，and their encapsulation rates were calculated.According to the single factor experiment，the factors that have a significant effect on its encapsulation efficiency were obtained.The best method for preparing liposomes was screened by orthogonal test design.Results:The optimal method obtained through orthogonal test was：lecithin：cholesterol 3:1，Xanthii Fructus oil：lecithin 1:7，and the volume of the hydration solution was 20 mL.Under this condition，the encapsulation rate was 68.0%.Conclusion:The encapsulation rate of liposomes obtained by this method is more than 60%，which is relatively stable.