To explore the possible mechanism of Huanglian Wendan Decoction in the treatment of Z syndrome based on network pharmacology and molecular docking.Methods:The active components and their corresponding targets of Huanglian Wendan Decoction were screened and collected on TCMSP and TCMID.Using UniProt database to obtain the target genes of the active components of drugs.Compared with the genes of human Z syndrome (OSAS combined with MS) obtained from the Genecards and OMIM databases，the potential target genes of Huanglian Wendan Decoction overlapped with Z syndrome were obtained.The network diagram of “disease-drug-component-target-pathway” of Huanglian Wendan Decoction was drawn by using the software of Cytoscape 3.7.2.The interaction data table between potential targets was obtained through string database，and then the interaction network diagram of target proteins was constructed by importing the software of Cytoscape 3.7.2.Then，based on the human gene annotation database org.Hs.eg.db provided by Bioconductor，the cluster filer package of R language was used to analyze the potential target of Huanglian Wendan Decoction in the treatment of Z syndrome by going classification enrichment analysis and KEGG pathway enrichment analysis.Results:There were 134 candidate active components，including luteolin，quercetin，scutellarin，baicalin，etc.; 65 potential targets，including AKT1，IL6，VEGFA and MMP-9; 116 pathways，including MAPK，NF kappa B，PI3K Akt，toll-like receptor and other signal pathways.Molecular docking showed that luteolin，quercetin and baicalein could bind to 3 key candidate target proteins (IL-6，AKT1 and MMP-9).Conclusion:Based on the network pharmacology method and molecular docking，the therapeutic target and signal pathway of Huanglian Wendan Decoction in the treatment of Z syndrome are excavated，which provides a new research method for the study of the mechanism of Huanglian Wendan Decoction in the treatment of OSAS，and also provides a new idea for the further study of the mechanism of treating different diseases with the same therapeutic principle in traditional Chinese medicine.