To explore the possible mechanism of Shengyang Chushi Decoction on chronic enteritis.Methods:A total of 136 patients admitted to Suizhou Hospital Affiliated to Hubei University of Medicine with chronic enteritis were selected as the research objects and were divided into a control group (n=68) and an observation group (68 cases).The control group was treated with mesalazine,and the observation group was treated with mesalazine+Shengyang Chushi Decoction.The changes of oxidative stress factor,intestinal mucosal barrier,inflammatory factor,immune function and TCM symptom score before and after treatment were observed and compared between the 2 groups.The efficacy was compared after the completion of 8 weeks of treatment.Results:The observation group had more advantages than mesalazine group in improving SOD,IL-10,CD3+,CD4+,CD4+/CD8+,and down regulating MAD,DAO,D-lactic acid,IL-6,IL-17,TNF-α,IgA,IgM,IgG,CD8+ levels (P<0.05),and had obvious advantage in abdominal pain,abdominal distension,diarrhea,tenesmus,fatigue,nausea and vomiting,anorexia.The cure rate of Shengyang Chushi group was 39/71%,and the total effective rate was 91.18%,which was significantly higher than that of the control group (22.06% and 79.41%,P<0.05).Conclusion:Modified Shengyang Chushi Decoction can inhibit the oxidative stress of chronic enteritis,protect intestinal mucosal barrier,inhibit inflammatory reaction,promote the recovery of immune function,so as to improve the clinical symptoms of enteritis and improve the curative effect.