To Chinese Medicine combined with chemotherapy on reducing toxicity and increasing efficiency of sequential therapy in the treatment non-smallcell lung cancer.Methods:A total of 100 patients with non-small cell lung cancer diagnosed by imaging and pathology or cytology were randomly divided into an observation group and a control group,with 50 patients in each group.The control group received chemotherapy.The observation group received sequential oral administration of Chinese medicine on the basis of routine chemotherapy.After 4 cycles,the clinical efficacy and toxicity of the 2 groups were observed.Results:A total 91 patients were finally included.After treatment,the observation group was higher than the control group in general condition (KPS),improvement of clinical symptoms and clinical benefit rate (P<0.05),and the incidence of nausea,vomiting (including acute and delayed vomiting),loss of appetite and other gastrointestinal toxicity,anemia,leukopenia,myelotoxicity,and other cancer fatigue were lower than the control group (P<0.05).There was no significant difference in the incidence of thrombocytopenia decrease,liver and kidney function damage,Hypoesthesia,neurotoxicity,allergic reaction and other toxic reactions (P>0.05).Conclusion:The sequential treatment of traditional Chinese medicine combined with standard chemotherapy has the effect of increasing the efficacy and reducing the toxicity of NSCLC.It has certain clinical promotion significance.