To establish the HPLC specific chromatogram of Angelica sinensis and Angelica sinensis body,and to provide reference for the quality control of Angelica sinensis and Angelica body by the comparative analysis of the characteristic maps of Angelica sinensis and Angelica body．Methods:The HPLC analysis was performed on an Symmetry C18 column(250 mm×4.6 mm,5 μm) with acetonitrile-0.2% acetic acid solution as the mobile phase with gradient elution at a flow rate of 1.0 mL/min.The detection wavelength was 280 nm.The column temperature was 30 ℃.The flow rate was 1.0 mL/min,and the injection volume was 20 μL; Similarity evaluation system of chromatographic fingerprint of Chinese medicine was used to evaluate the similarity of 15 batches of Angelica sinensis and Angelica body in 3 production areas,and to establish the characterisics fingerprint of Angelica sinensis and Angelica body.Results:The specific chromatogram was preliminarily constructed and 4 common peaks of ferulic acid，senkyunolide I，senkyunolide H and ligustilide with ferulic acid as the reference were identified.The similarity of 15 batches of Angelica sinensis was greater than 0.96，and the similarity of 15 batches of angelica body was greater than 0.97.The characteristics of the HPLC specific chromatogram of Angelica sinensis and angelica body were similar，but the content of each component was different.Conclusion:The method is stable，reliable and reproducible，and can be used for quality control of Angelica sinensis and angelica body，and provide a basis for the development of famous classical formulas containing Angelica sinensis or angelica body.