To explore the potential active components and underlying molecular mechanisms of Qingfei Huatan Decoction to improve the hypersecretion of airway mucus in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)through the network pharmacology and molecular docking technology.Methods:First，the active components and potential targets of Qingfei Huatan Decoction were collected through the traditional Chinese medicine system pharmacology analysis platform(TCMSP)，and the targets related to airway mucus hypersecretion in AECOPD were screened by GeneCards database.Then，the disease target and the drug prediction target were intersected，and the intersection target network and protein interaction network were constructed with the help of Cytoscape 3.7.2 software，and the GO and KEGG enrichment analysis were performed by DAVID.Finally，the active ingredient of the drug was molecularly docked with the disease target.Results:A total of 54 effective active ingredients of Qingfei Huatan Decoction were obtained，which could act on AECOPD airway mucus hypersecretion through 67 potential targets，involving TNF signaling pathway，IL-17，epidermal growth factor receptor tyrosine kinase inhibitors resistance，PI3K-Akt，HIF-1，MAPK and other related signaling pathways.Molecular docking results showed that quercetin，luteolin，beta-sitosterol and other pharmaceutical active ingredients could bind to AKT1，IL6，EGF and other target proteins stably.Conclusion:The molecular docking technique reveals that Qingfei Huatan Decoction can directly improve the airway mucus hypersecretion of AECOPD and achieve therapeutic effects.Through the network pharmacology，the potential mechanism of its multi-target and multi-pathway was initially revealed，which provides ideas for further research．