To observe the effect of Fufangqishao anti-hypertension tablets(FHT)on inflammatory factors in serum and vascular Histology.Methods:The spontaneous hypertensive rats(SHR)were used as the experimental model，Wistar Kyoto rats were used as the control.FHT and Irbesartan were given by gavage.Purinoceptor P2Y6 inhibitor MRS2578 was used to interfere with the transmission of inflammatory response signals.The blood pressure，the expression of TNF-α,IL-6,IL-1 β and the vascular histology of rats under different treatments were measured.Results:FHT can significantly reduce the blood pressure of rats under different disposal.ELISA results showed that FHT can significantly reduce the content of TNF-α,IL-6,IL-1 β in serum.HE staining showed that FHT significantly promoted the recovery of vascular structure in rats.Conclusion:FHT inhibited the expression of inflammatory factors and promote the recovery of blood vessels.The effect of FHT may be related to inhibiting inflammatory reaction and promoting vascular recovery.