To explore the therapeutic mechanism of Qingxue Xiaozhi Formula(QXXZ) on atherosclerosis mice model via inhibiting FABP4 and promoting PPARγ in the aorta and liver.Methods:A total of 45 ApoE-knockout (ApoE-/-) mice fed with high-fat diet for 9 weeks were randomly divided into a model group (n=15),a Lipitor group (n=15) and a QXXZ group(n=15).For an additional 9 weeks with high-fat diet and drug intervention,blood lipids and homocysteine (Hcy) in serum,plaque areas in aorta,and collagen fibers in plaques were determined.The mRNA and protein expression levels of FABP4,PPARα and PPARγ in the liver and aorta were measured.Results:1) QXXZ significantly decreased the TGs,LDL-C and Hcy levels compared with the model group.And it significantly reduced the relative area of aortic plaque (P<0.05) 2) QXXZ significantly reduced FABP4 protein expression levels in the aorta (P<0.05),and promoted PPARγ mRNA and protein expression levels (P<0.05); at the same time,QXXZ can significantly reduce FABP4 protein expression levels in the liver and promote the protein expression of PPARγ (P<0.05).Conclusion:QXXZ has a certain preventive effect on atherosclerosis,and its mechanism may be related to significantly reducing the mRNA and protein expression levels of FABP4 in the aorta and liver,and promoting the expression of PPARγ.