To explore the application value of Shenmai Injection in the treatment of patients with acute ST-segment elevation myocardial infarction (STEMI) percutaneous coronary intervention (PCI) with deficiency of both qi and yin,and to observe its effect on lipoprotein phospholipase in patients A2 (Lipoprotein phospholipase A2,Lp-PLA2),Interleukin-1β (IL-1β) and the influence of heart function,to provide effective treatment for this disease.Methods:From November 2016 to September 2018,a total of 89 patients with the deficiency of both qi and yin due to STEMI admitted to Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine were selected as the research objects and were divided into a control group (n=45) and an observation group (n=44) according to the random number table.The control group was treated with percutaneous coronary intervention alone,and the observation group was treated with Shenmai Injection intravenously.The clinical efficacy was compared after 4 weeks of treatment.Results:The venous blood was collected from the elbow before and after treatment.After 48 hours of treatment,the levels of troponin (cTnT) and creatine kinase isoenzyme (CK-MB) in the observation group were lower than those in the control group,the difference was statistically significant (P<0.05).After 4 weeks of treatment,the levels of Amino terminal brain natriuretic peptide precursor (NT-proBNP),LP-PLA2 and IL-1β in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).After treatment,the ratio of early to late diastolic flow velocity (E/A) and left ventricular ejection fraction (LVEF) of the observation group were greater than those of the control group,and the left ventricular end diastolic diameter (LVEDD) level was lower than the control group,the difference between statistical significance (P<0.05); After treatment,the scores of symptoms such as fatigue,poor stomach appetite and five upset fever in the observation group were all lower than those in the control group (P<0.05).The total effective rate of electrocardiogram in the observation group was 95.45% (42/44),which was higher than the control group 75.56% (34/45),the difference was statistically significant (P<0.05).The total incidence of death,severe arrhythmia,heart failure,angina and other complications within 4 weeks of treatment in the observation group was lower than that in the control group (P<0.05).Conclusion:For patients with STEMI (deficiency of both qi and yin) treated with percutaneous coronary intervention therapy,the combination of Shenmai Injection is of great significance,which can reduce ischemia reperfusion injury and improve the prognosis of myocardial infarction,and is worthy of promotion.